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KMID : 1037120140320030139
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The World Journal of Men′s Health
2014 Volume.32 No. 3 p.139 ~ p.144
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Relationship between Serum Testosterone and Cardiovascular Disease Risk Determined Using the Framingham Risk Score in Male Patients with Sexual Dysfunction
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Lee Wan-Chul
Kim Ma-Tae
Ko Kyung-Tae
Lee Won-Ki
Kim Sung-Yong
Kim Ha-Young
Yang Dae-Yul
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Abstract
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Purpose: The aim of the present study aimed to evaluate the effect of testosterone on cardiovascular disease by using the
Framingham Risk Score (FRS) in patients with sexual dysfunction.
Materials and Methods: A total of 308 men with sexual dysfunction were enrolled in this study. Clinical assessments included the 15-item International Index of Erectile Function (IIEF), blood pressure measurement, and clinical laboratory indexes. The FRS, which predicts the incidence rate of cardiovascular diseases in the next 10 years, was calculated on the basis of age, gender, total cholesterol, smoking status, high density lipoprotein cholesterol, and systolic blood ressure.
Results: The mean age of the 308 enrolled patients was 49.42±10.73 years, and the patients’ mean body mass index (kg/m2) was 25.07±3.14. The mean total IIEF score was 28.44±18.06. The median total testosterone concentration was 3.2 ng/mL(interquartile range [IQR]: 2.3∼3.2 ng/mL). The median calculated free and bioavailable testosterone concentrations were 0.052ng/mL (IQR 0.039∼0.070 ng/mL) and 1.30 ng/mL (IQR: 1.00∼1.76 ng/mL), respectively. The mean FRS was 10.47±6.45. The FRS tended to show a negative correlation with the total and calculated free testosterone levels, but this was not significant (p=0.064 and p=0.074, respectively). In the multiple linear regression analysis, a significant negative correlation was observed between the total testosterone level and the FRS (p=0.048).
Conclusions: The results suggest that the testosterone level is related to the FRS and that a high testosterone level may decrease the risk of cardiovascular disease.
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KEYWORD
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Cardiovascular diseases, Sexual dysfunction, Testosterone
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